Allogeneic Bone marrow transplant
Cost in India
Allogeneic Bone marrow transplant cost in India
Cost in India: $28000
| Surgery Name | Cost | Room-Category | Hospitalization |
|---|---|---|---|
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Allogeneic Bone marrow transplant cost in India |
$28000 |
Single |
stay of the patient in the hospital for up to 30 days |
| Inclusion | Exclusion |
|---|---|
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Pre Transplant work up for both patient and one donor |
If patient need desensitization therapy for high titer Donor Specific Antibodies |
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Donor specific antibody assay by Single bead assay (for Haplo HSCT only) |
If patient require Lymphodepletion chemo-Immunotherapy prior to Haplo HSCT |
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Donor Bone marrow/ Peripheral blood stem cell harvesting |
Patient with active malignancy (leukemia) on pre transplant assessment , who requires salvage chemotherapy cost of which would be USD 17000+/2000 depending on the disease status |
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Entire Transplant cost (over all 30 days maximum) |
Significant co morbidities at the time of transplant |
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GVHD requiring second line treatment (Refractory GVHD) |
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Platelet refractory requiring multiple transfusion and prolonged stay |
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Major ICU stay |
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Stay exceeding 30 days |
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Any unrelated complication to Transplant |
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Any major readmission requiring prolonged hospitalization |
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If patient requiring Donor lymphocyte infusion, rescue transplant for primary graft failure or stem cell top up infusion, CMV reactivation requiring prolonged hospitalization and supportive treatment |
Need for stay in India after transplant:
Allogeneic bone marrow transplant — The term allo means other. Stem cells are removed from another person, called a donor. Most times, the donor’s genes must at least partly match your genes. Special tests are done to see if a donor is a good match for you. A brother or sister is most likely to be a good match. Sometimes parents, children, and other relatives are good matches. Donors who are not related to you, yet still match, may be found through national or bone marrow registries.
What is Bone Marrow Transplant?
A bone marrow transplant is a step to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue inside your bones. The bone marrow produces blood cells. Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells. Before the transplant, chemotherapy, radiation, or both may be given to the patient. This may be done in two ways:
- Ablative (myeloablative) treatment — High-dose chemotherapy, radiation, or both are given to kill any cancer cells. This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow.
- Reduced intensity treatment, also called a mini transplant — Lower doses of chemotherapy and radiation are given before a transplant. This allows older people, and those with other health problems to have a transplant.
Who needs a bone marrow transplant?
Doctors use bone marrow transplants to treat people with a range of malignant and non-malignant diseases, including these:
- Acute leukemia
- Aplastic Anemia
- Thalassemia
- Sickle Cell Anemia
- Pediatric Cancerous like neuroblastomas
- Pediatric Immunodeficiencies
- Adrenoleukodystrophy
- Aplastic anemia
- Bone marrow failure syndromes
- Chronic leukemia
- Hemoglobinopathies
- Hodgkin’s lymphoma
- Immune deficiencies
- Inborn errors of metabolism
- Multiple myeloma
- Myelodysplastic syndromes
- Neuroblastoma
- Non-Hodgkin’s lymphoma
- Plasma cell disorders
- POEMS syndrome
Who can Donate Bone Marrow ?
- Anyone from patient family , suitable donor
- One can donate bone marrow through bone marrow registry after the transplant
(The donor can be a family member or someone unrelated to you. Sometimes, people get donated blood-forming cells from umbilical cord blood. Blood and tissue test are done prior to the transplant).
(One cannot donate during the transplant because one has to undergo blood and tissue test to ensure transplant is a success)
What are the common complications & Risks which can arise with a Bone Marrow Transplant?
A bone marrow transplant poses numerous risks. Some people experience minimal problems with a bone marrow transplant, while others can have serious complications that require treatment or hospitalization. Sometimes, complications are life-threatening.
Possible complications from a bone marrow transplant include:
- Graft-versus-host disease (allogeneic transplant only)
- Stem cell (transplant) failure.
- Organ damage.
- Infections.
- Cataracts.
- Infertility.
- New cancers.
- Death.
What is the Success Rates of Bone Marrow Transplant?
Bone marrow transplant (BMT) has a predictable survival rate of nearly more than 60 percent. Every bone marrow transplant (BMT) case survival varies depending upon the type of transplant chosen like allogeneic or autologous. Even the complete replacement or removal of diseases marrow cells is not enough sometimes although it does efficiently work in most of the cases of transplant. The success and survival rates of any bone marrow transplant (BMT) depends greatly on patient’s condition and requirement. Bone marrow transplant (BMT) does cure some of the diseases and helps in extending life and improves the quality of life as well. But in some rare cases treating one disease leads to remission of another during or after the treatment. But those risks and complications and their chances can be discussed with a specialized doctor before undergoing a bone marrow transplant (BMT).
How long Patient lives or survive after a bone marrow transplant?
People undergoing a bone marrow transplant (BMT) in India have a good survival rate. India has emerged as a global hub for several affordable but highly effective treatments. So any treatment in India including a bone marrow transplant (BMT) does have a good survival rate like in any other standard developed country but they charge too much unlike Indian economic. Several statistical data has been accumulated to date to support good survival rates offered by Indian BMT done for several diseases and age group patients. A relevant data states that nearly 30% to 40% of above 60 age group patients do survive more than 3 years after BMT done in India. The survival chances increase if younger is the patient age who are being treated and early is the diagnosis stage of the disease. Further, no reoccurrence until 2 years after BMT, even improves the chances of disease-free and longer survival -).
When your liver is damaged beyond repair, chronic or acute, severe liver disease leading to liver failure can be considered for a liver transplant.
The following conditions may result in chronic liver failure:
- Chronic hepatitis with cirrhosis
- Primary biliary cholangitis (previously called primary biliary cirrhosis, it is a rare condition where the immune system inappropriately attacks and destroys the bile ducts)
- Sclerosing cholangitis (scarring and narrowing of the bile ducts inside and outside of the liver, causing the backup of bile in the liver)
- Biliary atresia (a rare disease of the liver that affects newborns)
- Alcoholism
- Wilson’s disease (a rare inherited disease with abnormal levels of copper throughout the body, including the liver)
- Hemochromatosis (a common inherited disease where the body has too much iron)
- Alpha-1 antitrypsin deficiency (an abnormal rise in alpha-1 antitrypsin protein in the liver, resulting in cirrhosis)
- Fatty Liver
- Viruses
- Liver Cancer
- Alcohol Abuse
- Metabolic Diseases
- Bile duct Diseases
- Tylenol Overdose
What are the cause of Liver Failure?
- Fatty Liver
- Viruses
- Liver Cancer
- Alcohol Abuse
- Metabolic Diseases
- Bile duct Diseases
- Tylenol Overdose
What are the Sign and Symptoms of Liver Failure?
- Jaundice
- Weakness
- Losing your appetite
- Feeling sick to the stomach
- Weight loss
- Itching
- Bleeding easily
- Throwing up blood
- Passing black stools
- Swollen abdomen
- Becoming forgetful or confused
What are the major risks in liver transplantation?
Risks include bleeding, poor function of the grafted liver, bile leaks infections. We monitor the patient carefully for several weeks after surgery for rejection. Rejection becomes less common with time.
What is the success rate of Liver Transplant in India?
In India, the success rate of Liver transplant has been 90%. But like any other transplant, liver transplant has its very own risks and complication.
What Are the Types of Liver Transplants?
Orthotropic Liver Transplantation is when the diseased liver is replaced by a healthy liver from a donor who has recently died. This is the most common procedure for liver transplants.
Living Donor Transplantation is when a living person donates a part of his or her liver to someone who needs a new liver. This procedure has been increasingly successful, but it carries risks for the donor, and only a small number of living donor transplants are available for patients with liver cancer.
What are the types of liver transplant?
Living Donor Liver Transplantation (LDLT): – Liver is transplanted with a part of a living donor’s healthy liver and removal of the diseased liver from the patient. The liver in both the donor & receiver then grows back to its normal size.
Cadaver Liver Transplantation: – Liver transplant is done with the healthy liver of a deceased person and removal of the diseased liver from the patient!
Domino Liver Transplantation: – Liver taken from a liver transplant recipient is placed into a second person with a liver disease and awaiting transplant. It is typically for elderly patients.
Split Liver Transplantation: – Liver transplant is performed by taking the healthy liver of a deceased person and splitting into two for transplanting into two patients and removal of the diseased liver from both the patients.
What Happens During Liver Transplant Surgery?
During transplant surgery, the transplant team replaces the diseased liver with a donated, healthy liver. The blood type and body size of the donor have to match the person receiving the transplant. Liver transplant surgery usually takes between 4 and 12 hours. Most patients stay in the hospital for up to 3 weeks after surgery.
How long Patient lives or survival after a Liver transplant?
According to a study, people who have a liver transplant have an 89% percent chance of living after one year. The five-year survival rate is 75 percent. Sometimes the transplanted liver can fail, or the original disease may return.
It’s important that your doctor monitors your recovery long after the transplant to detect any problems. You’ll likely need regular blood tests. you’ll also need to take antirejection medications for the rest of your life.
After How Many Days Living Liver Donor Can Resume his Normal Life?
After operation, the donor will stay in hospital for 5-10 days. Another 3-4 weeks of recuperation is required at home. After that, the donor can resume normal activity (except strenuous physical exercise) and return to work 6 weeks after surgery. Sexual activity can be resumed as soon as the donor feels well enough. Heavy physical activity, sports including lifting weights can be resumed 3 months after surgery.
What are the types of liver transplant?
Emergency Cases
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